Protect the USB connector
The USB connector is the part that enters the computer so that you can access your files. Dust and dirt can get into the connector thus causing short circuit that would damage the electronic components when you connect the USB to power. To avoid this you should keep the connector covered when not plugged into the computer. The best way of doing this is capping it. There are some drives that have a feature that makes it possible for you to extend the connector into the drive itself.
Watch how you remove it from the computer
If you are like most other people, once you are through with your work you yank out the USB drive from the computer. While doing this is fast, it can result to damage of the USB connector and the port of your computer. The best way of going about it is always going to the system tray icon “Safely Remove Hardware” and authorize the computer to remove the drive. When you use this process you ensure that you shut down communication between your computer and USB drive; therefore, you avoid damage.
Protect it from falls
To protect the drive and data inside, ensure that the drive doesn’t smash against the ground or slip through cracks. The best way of protecting your drive is keeping it inside a cover or enchaining it with a key-ring.